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KMID : 0376219840210040937
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Chonnam Medical Journal
1984 Volume.21 No. 4 p.937 ~ p.950
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Chemotherapy of Cervical Carcinoma
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Abstract
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Chemotherapy for cervical cancer has been regarded as least potent, and it has played no significant role in the treatment of this cancer. But, it is indicated in the treatment of stage IV cervical cancer and in patients with tumor recurrence previously treated with radical surgery or radiation therapy. The past decade has seen an increasing number of reports on the efficacy of various chemotherapeutic agents in the treatment of squamous cell carcinoma of the cervix. Summaries of these reports are as the following.
1. The most effective single agent was Cis-platinum.
2. The responses of adriamycin combinations were short duration and associated with significant toxicity.
3. In breomycin and mitomycin-C combination, a complete response rate of 66 % was reported by Miyamoto, but the later studies did not confirm the high response rates.
4. Cis-platin containing regimens are among the most promising combinations found to date.
5. By Sugawa, the accumulated recurrence rate in 5 years was 9. 7 % in the postoperative chemotherapy group, compared with 36. 0% in control group.
6. Piver and associates reported that, in women with stage llb cervical cancer, five-year survival rate for the cases given hydroxyurea at radiation therapy was 94% as compared to 53% for the cases given placebo.
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KEYWORD
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